Correlation of electrogastrography and gastric emptying rate estimated by C-octanoic acid breath test in healthy volunteers
نویسندگان
چکیده
2 Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic Institute of Clinical Biochemistry and Diagnostics, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic Department of Medical Biophysics, Charles University in Praha, Faculty of Medicine at Hradec Králové, Czech Republic Department of Paediatrics, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic
منابع مشابه
Pharmacological modulation of gastric emptying rate of solids as measured by the carbon labelled octanoic acid breath test: influence of erythromycin and propantheline.
The *C (13C or 14C) labelled octanoic acid breath test was recently developed to measure the gastric emptying rate of solids. This study aimed to investigate whether it is sensitive enough to detect pharmacologically induced changes in the gastric emptying rate. Nine healthy volunteers were studied in basal condition, after intravenous administration of 200 mg erythromycin, and after peroral ad...
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems. Subclinical involvement of the autonomic system in ALS has been described. The recently developed (13)C-octanoic acid breath test allows the noninvasive measurement of gastric emptying. With this new tec...
متن کاملArt. 1.1397
Principle of 13C-octanoic Acid Breath Test The rationale of 13C-octanoic acid breath test (13C-OBT) to measure gastric emptying of solids is based on (1) the firm retention of 13C-octanoic acid in the solid phase of a standard test meal during its passage through the gastric environment, followed by (2) a rapid disintegration of the solid phase in the duodenum with (3) subsequent absorption of ...
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Recently, we developed the [13/14C]octanoic acid breath test to measure gastric emptying of solids. Although the method has been validated extensively, absorption, metabolism, and excretion of the label in the breath need to be corrected for. In this study a mathematical model was developed that allows for 1) separation of the global CO2 excretion after ingestion of the labeled test meal into t...
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Although scintigraphy, a non-invasive procedure, is usually considered to be the reference technique for measuring gastric emptying in humans, several drawbacks limit its application in routine practice. Expensive equipment is required and access to a nuclear medicine department, and the use of radioactive isotopes (generally Tc and In) can produce low but significant irradiation. It is diYcult...
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